abstract：:Several neurotransmitter receptors have been proposed to be involved in memory formation. However, information on receptor complexes (RCs) in the radial arm maze (RAM) is missing. It was therefore the aim of this study to determine major neurotransmitter RCs levels that are modulated by RAM training because receptors ...

journal_title：Behavioural brain research

authors： Shanmugasundaram B,Sase A,Miklosi AG,Sialana FJ,Subramaniyan S,Aher YD,Gröger M,Höger H,Bennett KL,Lubec G

更新日期：2015-08-01 00:00:00

abstract：:Chronic restraint stress (CRS) causes hippocampal neurodegeneration and hippocampus-dependent cognitive deficits. Flupirtine represents neuroprotective effects and we have previously shown that flupirtine can protect against memory impairment induced by acute stress. The present study aimed to investigate whether flup...

journal_title：Behavioural brain research

authors： Huang P,Li C,Fu T,Zhao D,Yi Z,Lu Q,Guo L,Xu X

更新日期：2015-07-15 00:00:00

abstract：:Growing evidence suggests that testosterone may play a role in the pathophysiology of schizophrenia given that testosterone has been linked to cognition and negative symptoms in schizophrenia. Here, we determine the extent to which serum testosterone levels are related to neural activity in affective processing circui...

journal_title：Behavioural brain research

authors： Ji E,Weickert CS,Lenroot R,Catts SV,Vercammen A,White C,Gur RE,Weickert TW

更新日期：2015-06-01 00:00:00

abstract：:This study investigated the possible influence of the Subdural Pharmacotherapy Device (SPD) on spatial memory in 3 adult, male bonnet macaques (Macaca radiata). The device was implanted in and above the subdural/subarachnoid space and cranium overlaying the right parietal/frontal cortex: a circuitry involved in spatia...

journal_title：Behavioural brain research

authors： Ludvig N,Tang HM,Baptiste SL,Stefanov DG,Kral JG

更新日期：2015-06-01 00:00:00

abstract：:When making choices under uncertainty, people usually consider both the risks and benefits of each option. Previous studies have found that weighing of risks and benefits during decision-making involves a complex neural network that includes the dorsolateral prefrontal cortex (DLPFC), but the causal effect of this net...

journal_title：Behavioural brain research

authors： Ye H,Chen S,Huang D,Wang S,Luo J

更新日期：2015-06-01 00:00:00

abstract：:There is no satisfactory therapeutic intervention for neonatal hypoxic-ischemic (HI) encephalopathy. Progesterone is known to be effective in treating traumatic brain injury in adult animals but its effects in neonatal brains have not been reported. Brain injuries were induced by a unilateral common carotid artery lig...

journal_title：Behavioural brain research

authors： Peterson BL,Won S,Geddes RI,Sayeed I,Stein DG

更新日期：2015-06-01 00:00:00

abstract：:The present study investigated the impact of a spared nerve injury (SNI) on the daily performance of rats tested in two instrumental conditioning procedures: the progressive ratio (PR) schedule of food reinforcement to study motivation for an appetitive stimulus, and the 5-choice serial reaction time task (5-CSRTT), a...

journal_title：Behavioural brain research

authors： Higgins GA,Silenieks LB,Van Niekerk A,Desnoyer J,Patrick A,Lau W,Thevarkunnel S

更新日期：2015-06-01 00:00:00

abstract：:Animals treated with unilateral 6-hydroxydopamine (6-ODHA) injections, an animal model of Parkinson's disease, exhibit deficits in memory for temporal order, but show intact novel object recognition. Since senktide, a potent neurokinin-3 receptor (NK3-R) agonist, has been shown to have promnestic effects in the aged r...

journal_title：Behavioural brain research

authors： Chao OY,Wang AL,Nikolaus S,de Souza Silva MA

更新日期：2015-05-15 00:00:00

abstract：:Experience-dependent synaptic plasticity is widely expressed in the mammalian brain and is believed to underlie memory formation. Persistent forms of synaptic plasticity in the hippocampus, such as long-term potentiation (LTP) and long-term depression (LTD) are particularly of interest, as evidence is accumulating tha...

journal_title：Behavioural brain research

authors： Goh JJ,Manahan-Vaughan D

更新日期：2015-05-15 00:00:00

abstract：:Research into object recognition memory has been galvanised by the introduction of spontaneous preference tests for rodents. The standard task, however, contains a number of inherent shortcomings that reduce its power. Particular issues include the problem that individual trials are time consuming, so limiting the tot...

journal_title：Behavioural brain research

authors： Kinnavane L,Albasser MM,Aggleton JP

更新日期：2015-05-15 00:00:00

abstract：:Three-dimensional objects are common stimuli that rodents and other animals encounter in the natural world that contribute to the associations that are the hallmark of explicit memory. Thus, the use of 3-dimensional objects for investigating the circuits that support associative and episodic memories has a long histor...

journal_title：Behavioural brain research

authors： Burke SN,Barnes CA

更新日期：2015-05-15 00:00:00

abstract：:Rats readily learn to anticipate a reward signaled by an external stimulus. Anticipatory behaviors evoked by conditioned stimuli include 50 kHz ultrasonic vocalizations (USVs), a proposed behavioral correlate of positive affect and activation of midbrain dopamine pathways. Rats can also anticipate a reward, such as fo...

journal_title：Behavioural brain research

authors： Opiol H,Pavlovski I,Michalik M,Mistlberger RE

更新日期：2015-05-01 00:00:00

abstract：:The aim of study was to search for new biomarkers with a magnetic resonance technique to identify the early stages of dementia, induced by D-galactose, and evaluate Simvastatin therapy. Localized proton magnetic resonance spectroscopy measurements showed a significant decrease in the concentration of N-acetylaspartate...

journal_title：Behavioural brain research

authors： Tušková R,Lipták B,Szomolányi P,Vančová O,Uličná O,Sumbalová Z,Kucharská J,Dubovický M,Trattnig S,Liptaj T,Kašparová S

更新日期：2015-05-01 00:00:00

abstract：:Oxycodone and hydrocodone are opioids which are widely used for pain management and are also commonly misused and abused. The exposure to opioid analgesics has been associated with altered responses of D2-like dopamine receptors (D2DRs). Our recent results suggest that various opioids will differentially modulate the ...

journal_title：Behavioural brain research

authors： Emery MA,Bates ML,Wellman PJ,Eitan S

更新日期：2015-05-01 00:00:00

abstract：:Exaggerated avoidance behavior is a predominant symptom in all anxiety disorders and its degree often parallels the development and persistence of these conditions. Both human and non-human animal studies suggest that individual differences as well as various contextual cues may impact avoidance behavior. Specifically...

journal_title：Behavioural brain research

authors： Sheynin J,Moustafa AA,Beck KD,Servatius RJ,Myers CE

更新日期：2015-04-15 00:00:00

abstract：:Parent-offspring interactions early in life can permanently shape the developmental path of those offspring. Manipulation of maternal care has long been used to alter the early-life environment of infants and impacts their later social behavior, aggression, and physiology. More recently, naturally occurring variation ...

journal_title：Behavioural brain research

authors： Perkeybile AM,Bales KL

更新日期：2015-04-15 00:00:00

abstract：:Social isolation rearing (isolated condition, IC) is used as a model of early life stress in rodents. Rats raised in this condition are often compared to rats raised in an environmentally enriched condition (EC). However, EC rats are repeatedly exposed to forced novelty, another classic stressor in rodents. These stud...

journal_title：Behavioural brain research

authors： Hofford RS,Prendergast MA,Bardo MT

更新日期：2015-04-15 00:00:00

abstract：:Alcohol abuse is a major medical problem. Zebrafish have been proposed to model alcohol related human disorders. Alcohol impairs learning and memory. Here, we analyze the effects of alcohol on performance of zebrafish in a recently developed latent learning paradigm. We employ a 2×3×2 experimental design (chronic×acut...

journal_title：Behavioural brain research

authors： Luchiari AC,Salajan DC,Gerlai R

更新日期：2015-04-01 00:00:00

abstract：:Chronic restraint stress alters hippocampal-dependent spatial learning and memory in a sex-dependent manner, impairing spatial performance in male rats and leaving intact or facilitating performance in female rats. Moreover, these stress-induced spatial memory deficits improve following post-stress recovery in males. ...

journal_title：Behavioural brain research

authors： Ortiz JB,Taylor SB,Hoffman AN,Campbell AN,Lucas LR,Conrad CD

更新日期：2015-04-01 00:00:00

abstract：:The posteromedial cortex including the precuneus (PC) is thought to be involved in episodic memory retrieval. Here we used continuous theta burst stimulation (cTBS) to disentangle the role of the precuneus in the recognition memory process in a sample of healthy subjects. During the encoding phase, subjects were prese...

journal_title：Behavioural brain research

authors： Bonnì S,Veniero D,Mastropasqua C,Ponzo V,Caltagirone C,Bozzali M,Koch G

更新日期：2015-04-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) is known to play physiologically and pathologically crucial roles in the central nervous system. However, it is still obscure whether it affects social behavior. We investigated social behavior and neuronal activation after social stimulation in tPA knockout (KO) mice. In a resident-...

journal_title：Behavioural brain research

authors： Nakamura K,Takabe A,Shimizu F,Takahashi M,Matsuo O,Mitsui S

更新日期：2015-03-15 00:00:00

abstract：:The complex bidirectional communication between the central nervous system and the peripheral immune system is of possible relevance for both normal brain functions and the development of psychiatric disorders. The aim of this investigation was to study central expression of inflammatory markers in a genetic rat model...

journal_title：Behavioural brain research

authors： Strenn N,Suchankova P,Nilsson S,Fischer C,Wegener G,Mathé AA,Ekman A

更新日期：2015-03-15 00:00:00

abstract：:The Uba6-Use1 ubiquitin enzyme cascade is a poorly understood arm of the ubiquitin-proteasome system required for mouse development. Recently, we reported that Uba6 brain-specific knockout (termed NKO) mice display abnormal social behavior and neuronal development due to a decreased spine density and accumulation of U...

journal_title：Behavioural brain research

authors： Lee JY,Kwak M,Lee PC

更新日期：2015-03-15 00:00:00

abstract：:Dopamine (DA) is well known for its involvement in novelty-seeking, learning, and goal-oriented behaviors such as social behavior. However, little is known about how DA modulates social processes differentially in relation to sex and behavioral phenotype (e.g., personality). Importantly, the major DA cell groups (A8-A...

journal_title：Behavioural brain research

authors： Kelly AM,Goodson JL

更新日期：2015-03-01 00:00:00

abstract：:Working with mice represents a smart method to study pathophysiological mechanisms in vivo. However, using animals as model organisms also bears immense caveats. While many aspects in animal research are meanwhile standardized (e.g. nutrition, housing, health) the breeding environment remains unaddressed. Moreover, si...

journal_title：Behavioural brain research

authors： Lerch S,Brandwein C,Dormann C,Gass P,Chourbaji S

更新日期：2015-02-15 00:00:00

abstract：:The relevance of adult neurogenesis in hippocampal function is well documented, as is the potential impact stress has on the adult neurogenic niche. Adult born neurons are generated from neural precursors in the dentate gyrus (DG), although the point in postnatal development that these cell precursors originate is not...

journal_title：Behavioural brain research

authors： Ortega-Martínez S,Trejo JL

更新日期：2015-02-15 00:00:00

abstract：:The selective CRF₁ (corticotropin releasing factor type 1) receptor antagonist SSR125543 has been previously shown to attenuate the long-term behavioral and electrophysiological effects produced by traumatic stress exposure in mice. Sleep disturbances are one of the most commonly reported symptoms by people with post-...

journal_title：Behavioural brain research

authors： Philbert J,Beeské S,Belzung C,Griebel G

更新日期：2015-02-15 00:00:00

abstract：:There is emerging evidence for a dopamine (DA)-serotonin (5-HT) interaction underlying obsessive-compulsive disorder (OCD). In the quinpirole sensitization rat model of OCD, compulsive checking is induced by chronic treatment with the DA agonist quinpirole, and is attenuated by the 5-HT agonist drug mCPP. However, mCP...

journal_title：Behavioural brain research

authors： Tucci MC,Dvorkin-Gheva A,Johnson E,Wong M,Szechtman H

更新日期：2015-02-15 00:00:00

abstract：:Age-related cognitive decline has been accounted for by an age-related deficit in top-down attentional modulation of sensory cortical processing. In light of recent behavioral findings showing that age-related differences in selective attention are modality dependent, our goal was to investigate the role of sensory mo...

journal_title：Behavioural brain research

authors： Guerreiro MJ,Eck J,Moerel M,Evers EA,Van Gerven PW

更新日期：2015-02-01 00:00:00

abstract：:The aim of this study was to investigate the effects of Ginkgo biloba extract (GBE) on cognitive functions as well as oxidative stress and brain-derived neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or vehic...

journal_title：Behavioural brain research

authors： Belviranlı M,Okudan N

更新日期：2015-02-01 00:00:00

abstract：:The ability to understand speech under adverse listening conditions deteriorates with age. In addition to genuine hearing deficits, age-related declines in attentional and inhibitory control are assumed to contribute to these difficulties. Here, the impact of task-irrelevant distractors on speech perception was studie...

journal_title：Behavioural brain research

authors： Getzmann S,Falkenstein M,Wascher E

更新日期：2015-02-01 00:00:00

abstract：:Esthetic experience is a unique, affectively colored, self-transcending subject-object relationship in which cognitive processing is felt to flow differently than during everyday experiences. Notwithstanding previous multidisciplinary investigations, how esthetic experience modulates perception is still obscure. We us...

journal_title：Behavioural brain research

authors： Boccia M,Nemmi F,Tizzani E,Guariglia C,Ferlazzo F,Galati G,Giannini AM

更新日期：2015-02-01 00:00:00

abstract：:Gangliosides are compounds that are abundant throughout the CNS, participating actively in neuroplasticity. We previously described that exogenous GM1 ganglioside pretreatment enhances the rewarding properties of cocaine, evidenced by a lower number of sessions and/or dosage necessary to induce conditioned place prefe...

journal_title：Behavioural brain research

authors： Valdomero A,Perondi MC,Orsingher OA,Cuadra GR

更新日期：2015-02-01 00:00:00

abstract：:Classical eyeblink conditioning (EBC), a simple form of associative learning, has long been served as a model for motor learning and modulation. The neural circuitry of EBC has been studied in detail in rabbits. However, its underlying molecular mechanisms remain unclear. The advent of mouse transgenics has generated ...

journal_title：Behavioural brain research

authors： Yang Y,Lei C,Feng H,Sui JF

更新日期：2015-02-01 00:00:00

abstract：:Heavy prenatal alcohol exposure results in a range of deficits, including both volumetric and functional changes in brain regions involved in response inhibition such as the prefrontal cortex and striatum. The current study examined blood oxygen level-dependent (BOLD) response during a stop signal task in adolescents ...

journal_title：Behavioural brain research

authors： Ware AL,Infante MA,O'Brien JW,Tapert SF,Jones KL,Riley EP,Mattson SN

更新日期：2015-02-01 00:00:00

abstract：:Taste memory depends on motivational and post-ingestional consequences after a single taste-illness pairing. During conditioned taste aversion (CTA), the taste and visceral pathways reach the nucleus of the solitary tract (NTS), which is the first relay in the CNS and has a vital function in receiving vagal chemical s...

journal_title：Behavioural brain research

authors： García-Medina NE,Vera G,Miranda MI

更新日期：2015-02-01 00:00:00

abstract：:Serotonin plays a major role in sensory processing especially with in the primary auditory cortex. The so-called loudness dependence of auditory evoked potentials is generated by pyramidal cells of the primary auditory cortex (LDAEP) which are modulated by serotonergic projection fibers to the main regulators of pyram...

journal_title：Behavioural brain research

authors： Juckel G

更新日期：2015-01-15 00:00:00

abstract：:Serotonin has been implicated in the control of satiety for almost four decades. Historically, the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has stimulated interest in and research into the role of this neurotransmitter in satiety. Various rodent models, including transgenic m...

journal_title：Behavioural brain research

authors： Voigt JP,Fink H

更新日期：2015-01-15 00:00:00

abstract：:On the basis of between subjects monitoring of in vivo dopamine (DA) transmission in the rat nucleus accumbens (NAc) shell and core during response-contingent and non-contingent sucrose feeding we have hypothesized that long term, daily exposure to sucrose feeding results in the acquisition of conditioned/discriminati...

journal_title：Behavioural brain research

authors： Bassareo V,Cucca F,Frau R,Di Chiara G

更新日期：2015-01-01 00:00:00

abstract：:Integrating research efforts using a cross-domain approach could redefine traditional constructs used in behavioral and clinical neuroscience by demonstrating that behavior and mental processes arise not from functional isolation but from integration. Our research group has been examining the interface between cogniti...

journal_title：Behavioural brain research

authors： Cromwell HC,Atchley RM

更新日期：2015-01-01 00:00:00